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KMID : 0352519830200030093
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Korea Univercity Medical Journal
1983 Volume.20 No. 3 p.93 ~ p.101
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An Experimental Study of Intrauterine Administration of Indomethacin on the Ovary and Plasma Hormone Levels in Pseudopregnant Rabbits
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朴俊相/Park, Joon-Sang
羅重烈/李壽鍾/Na, Joong-Yol/Lee, Soo-Chong
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Abstract
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The effects of intrauterine administration of indomethacin on the ovary and plasma steroid hormones icere studied. Pseudopregnancy was induced in seven rabbits by the injection of 50 ug of ethinvl estradiol and 100 IU of hCG subcutar_ecusly. And these seven pseudcpregnant rabbits served as control group.
In the. indomethacin--treated group, pseudorregnar,cy was induced with 50 ug of ethinyl estradiol and 100 IU of hCG, and ip_dcmethacin was _mplanted in uterus on Day seven under laparotomy and uterine incision with pentothal anesthesia.
The plasma estrogen and progesterone level was determined by radicimmuncassay with about three days interval in both control and indomethacin-treated group.
The uterus and ovaries were submitted to histologic study on Day 30.
The following results were obtained;
1. Serum progesterone level in pseudopregnant rattits was decreased from 15th day of pseudopregnancy and returned to normal values by 18th day, while, in indomethacin-treated group, the high level of serum progesterone was maintained by 7 more days then control group.
2. Serum estrogen levels of pseudopregnant rabbit -,vas higher than pretreatment state and returned to normal value by 30th day, while, in indomethacin-treated group, the serum estrogen values was higher than control group and did not return to normal value by 30th day.
3. The corpus luteum regresses from 15th day in control group, but in indomethacin-treated group,. the corpus luteum was maintained till 25th day. The follicles are 4 to 5 in number in control group and 9 to 15 in indomethacin-treated group. The endometrium was papillary growth pattern in control group, but it was functionless in indomethacin-treated group. It seemed that the prostaglandin from the endometrium acts on corporal regression, but it´s action on the follicles was different from that on corpus luteum.
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